Single-molecule Theory of Biological Motors. Sándor Volkán-Kacsó Research Lab.

Fueled by ATP hydrolysis free energy, cellular nanomachinery works to realize functions such as muscle contraction, cell motility, cell division, protein transport, wound healing and DNA repair. Molecular motors are key in realizing these functions. Rotary motors (ATPases), linear motors (myosins, kinesins, dyenins) and revolving motors (viral packaging motors, DNA motor complexes), are stepping nano-machines and single-molecule imaging can be used to resolve the kinetic steps in relation to their mechanical displacement.